Endocrine Abstracts

Introduction: Liraglutide, a human GLP-1 analogue, is a new option for the treatment of type 2 diabetes (DM2). The purpose of this study was to evaluate the effects of liraglutide on cardiovascular risk factors in daily clinical practice in a heterogeneous population with DM2.Subjects and methods: Four visits were scheduled in a 1 year study (baseline, 4, 8 and 12 months). Patients with a HbA1c not on target (>7%) during an oral hypoglycemic treatmen...

Introduction: Generously supported by IPSEN)-->In children, GH secretion is considered sufficient when at least one value is >20 ng/ml at the GHRH + arginine (ARG) test. Because GH typically peaks at 45 min, we evaluated whether peak occurrence at one specific time is predictive of clinical outcomes in short stature children who are GH sufficient.Subjects and methods: Children who performed a GHRH plus ARG ...

GH secretion is usually impaired in active Cushing’s syndrome (CS), due to concomitant mechanisms, including diminished GHRH and/or increased somatostatin release and impaired pituitary somatotrope responsiveness. Differently, IGF1 levels not parallel GH insufficiency in CS, being reported reduced, normal or increased. Both ghrelin and GHRH+arginine (ARG) are powerful GH secretagogues, influenced by age and/or BMI. In 27 CS (42.7±2.9 years, 28.8±0.9 kg/m2</...

We present a novel heterozygous compound inactivating mutation of the CYP19A1 (P450arom) gene in a 26-year-old 46-XY Caucasian Italian male leading to aromatase deficiency. The patient phenotype resembled those observed in the other estrogen-deficient patients: tall stature with continuing linear growth, bilateral genu valgum, unfused epiphyses and delayed bone age, osteopenia. A dysmetabolic syndrome characterized by overweight (BMI 29), hyperinsulinaemia, low serum HDL and i...

Objective: Hypopituitarism in adults may be a consequence of TBI, but in the acute or long term management of TBI patients (ptx), endocrine evaluations are not usually included. Aim of this study was to investigate the prevalence of hypopituitarism and metabolic syndrome in a population of 54 severe (n=31) and moderate (n=23) TBI ptx (38 M, 16 F; age (mean±S.D.): 39.8±2.1 years) who had TBI more than 12 months before.<p class="abstext...

Recent evidence shows that patients with traumatic brain injury (TBI) are at substantial risk of hypopituitarism. However, the pathomechanisms are still not completely understood. Little is known about the association of morphological changes in the sella region with pituitary function in TBI. In this study, we assessed morphological abormalities of the sella region in patients with TBI and their relation to endocrine function.We have studied MR or CT sc...

Background and aim: Information on incidence and prevalence of acromegaly usually originates from studies performed in referral endocrine care centers, whose catchment areas do not generally cover the entire population. Administrative databases can provide key information to assess the impact of acromegaly on patients and health systems. Our study aimed at estimating the prevalence and incidence data of acromegaly stratified by age and sex using data obtained in the Piedmont r...

BackgroundIn lipodystrophy (LD) adipose tissue function is impaired, leading to a severe metabolic syndrome. Familiar Partial LD (FPLD) type I (Kobberling Syndrome) overlaps with Cushing’s syndrome phenotype. The latter and the metabolic impairment observed in FPLD1 may suggest a crosstalk between the HPA axis, assuming that leptin sensitivity is preserved in this context. We aimed to evaluate if leptin levels are associated with glucocorticoid acti...

Lipodystrophy syndromes are a rare and heterogeneous disease characterized by loss of subcutaneous adipose tissue, deposition of fat in ectopic areas, and consequently metabolic impairment, and its recognition is based on physical examination and clinical history. Because of the complexity of the disease, pregnancy represents a dainty and challenging event, still understudied. Here we report a case of a 28 year-old Caucasian female followed for type 2 diabetes and hypertriglyc...

Background: The increase of global childhood obesity has led to an increase of associated co-morbidities also at a young age. The pro-inflammatory state and insulin resistance are two master regulators of several complications, including hypertension and pre-diabetes frequently connected in a complex cross-talk.Aim: To evaluate the relationship between glucose alterations and blood pressure and the pathogenetic involvement of the renin-aldosterone system...